MyBioSource.com's Toll-like receptor 4 antibody is a Rat monoclonal antibody. The Toll-like receptor 4 antibody was generated using ARMD10, Ly87, TLR4, toll, and toll like receptor 4 as the antigen. It reacts with Human. This antibody has been shown to work in applications such as: Functional Assay.
Description
Rat monoclonal Toll-like receptor 4 antibody
The MTS510 monoclonal antibody reacts with the mouse Toll-like receptor 4 /MD-2 complex. At least ten members of the Toll family have been identified. This family of type I transmembrane proteins is characterized by an extracellular domain with leucine-rich repeats and a cytoplasmic domain with homology to the type I IL-1 receptor. Two of these receptors, TLR2 and TLR4, are pattern recognition receptors and signaling molecules in response to bacterial lipoproteins and have been implicated in innate immunity and inflammation. TLR4 physically associates with MD-2, and together with CD14, this complex is responsible for LPS recognition and signaling. In the mouse, TLR4 is expressed by thioglycolate-elicited peritoneal macrophages. Incubation of peritoneal macrophages with LPS results in down regulation of surface TLR4/MD-2. The TLR4 gene is defective in C3H/HeJ and C57BL/10ScCr mice, both of which have been well characterized as hyporesponders to LPS. The MTS510 monoclonal antibody co-immunoprecipitates MD-2 and TLR4, and preferentially reacts with TLR4 that is associated with MD-2. In comparison, binding of the UT41 monoclonal antibody occurs with and without formation of the TLR4/MD-2 complex